trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride
trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride
CAS: 1314324-11-2
Molecular Formula: C15H16ClN
trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride - Names and Identifiers
| Name | trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride |
| Synonyms | trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride |
| CAS | 1314324-11-2 |
trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride - Physico-chemical Properties
| Molecular Formula | C15H16ClN |
| Molar Mass | 245.75 |
trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride - Introduction
trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine is an organic compound with the chemical formula C15H15ClN.
Nature:
-Appearance: White or off-white crystalline powder
-Melting point: approximately 192-195 ° C
-Soluble: Soluble in water and ethanol, slightly soluble in chloroform
Use:
trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine is widely used in the field of medicine. As an effective dielectric conductor, it is used in the synthesis of various organic compounds and drugs. It can be used as an antibacterial and insecticide, and also has applications such as anti-tumor and anti-epilepsy.
Method:
The preparation of trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride is usually carried out by the following steps:
1.4-brominated biphenyl reacts with sodium thiocyanate to generate 4-thiocyanate biphenyl.
2. The nucleophilic substitution reaction of 4-thiocyanatobiphenyl with cyclopropane alcohol produces trans-2-([[1,1 '-biphenyl]-4-yl) cyclopropane -1-OL.
3. Finally, trans-2-([[1,1 '-biphenyl]-4-yl) cyclopropan-1-ol reacts with hydrogen chloride to generate trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride.
Safety Information:
trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine the toxicity of hydrochloride is low, but it is still necessary to pay attention to safe operation. Contact with skin, eyes, and respiratory tract may cause irritation; Inhalation and contact should be avoided. In the process of use, should wear appropriate protective equipment, such as gloves, goggles, etc. And proper storage and disposal of waste compounds. When using in the laboratory, please follow the relevant safety operation procedures.
Nature:
-Appearance: White or off-white crystalline powder
-Melting point: approximately 192-195 ° C
-Soluble: Soluble in water and ethanol, slightly soluble in chloroform
Use:
trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine is widely used in the field of medicine. As an effective dielectric conductor, it is used in the synthesis of various organic compounds and drugs. It can be used as an antibacterial and insecticide, and also has applications such as anti-tumor and anti-epilepsy.
Method:
The preparation of trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride is usually carried out by the following steps:
1.4-brominated biphenyl reacts with sodium thiocyanate to generate 4-thiocyanate biphenyl.
2. The nucleophilic substitution reaction of 4-thiocyanatobiphenyl with cyclopropane alcohol produces trans-2-([[1,1 '-biphenyl]-4-yl) cyclopropane -1-OL.
3. Finally, trans-2-([[1,1 '-biphenyl]-4-yl) cyclopropan-1-ol reacts with hydrogen chloride to generate trans-2-([1,1'-biphenyl]-4-yl)cyclopropan-1-amine hydrochloride.
Safety Information:
trans-2-([1,1 '-biphenyl]-4-yl)cyclopropan-1-amine the toxicity of hydrochloride is low, but it is still necessary to pay attention to safe operation. Contact with skin, eyes, and respiratory tract may cause irritation; Inhalation and contact should be avoided. In the process of use, should wear appropriate protective equipment, such as gloves, goggles, etc. And proper storage and disposal of waste compounds. When using in the laboratory, please follow the relevant safety operation procedures.
Last Update：2024-04-09 21:00:56
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